At first — what is PICO-8?
PICO-8 is a virtual machine and game engine created by Lexaloffle Games. Games are written based on LUA language, you can play in browser or natively. “Cartridges” are png-files.
The most important difference in development is the token limit (8192). Tokens are variables, operators, etc. Thus, developers often have to be creative, plus the games are short (if they are not roguelikes).